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Year : 2014  |  Volume : 1  |  Issue : 2  |  Page : 65-69

Role of matrix metalloproteinases (MMPS) in periodontitis and its management

Department of Periodontics, K.S.R Institute of Dental Sciences and Research, K. S. R. Kalvi Nagar, Tiruchengode, Namakkal District, Tamil Nadu, India

Correspondence Address:
Dr. Esther Nalini Honibald
Professor, Department of Periodontics, K. S. R. Institute of Dental Sciences and Research, K. S. R. Kalvi Nagar, Tiruchengode - 637215, Namakkal District, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-3019.148262

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Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that mediate the degradation of extracellular matrix (ECM) macromolecules. The activity of MMPs is seen not only during normal organogenesis and wound healing, but also in pathological condition like inflammatory diseases. MMP synthesis and functions are regulated by transcriptional activation, post-transcriptional processing and by a family of endogenous inhibitors collectively known as tissue inhibitors of metalloproteinases (TIMPs). The balance of MMPs to TIMPs therefore determines matrix turnover, where either an excess of MMPs or a deficit of TIMPs may result in excess ECM degradation. This review describes the role of MMPs in periodontitis and its management.

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